NR4A nuclear receptors in immunity and atherosclerosis

• DOI: 10.1097/mol.0b013e3283643eac
• Publication Date: 2013-09-04T17:45:08Z
• Authors: Anouk A.J. Hamers; Richard N. Hanna; Heba Nowyhed; Catherine C. Hedrick; Carlie J.M. de Vries
• Keywords: 0303 health sciences; Endothelial Cells; Cell Differentiation; Atherosclerosis; T-Lymphocytes, Regulatory; Monocytes; 3. Good health; Mice; 03 medical and health sciences; Nuclear Receptor Subfamily 4, Group A, Member 2; Nuclear Receptor Subfamily 4, Group A, Member 1; Animals; Humans

To understand chronic inflammatory diseases such as atherosclerosis, we require in-depth knowledge on immune-cell differentiation, function of specific immune-cell subsets and endothelial cell-mediated extravasation. In this review, we summarize a number of very recent observations on the pivotal function of NR4A nuclear receptors in immunity and atherosclerosis.NR4A nuclear receptors are involved in negative selection of thymocytes, Treg differentiation and the development of Ly6C monocytes. Nur77 and Nurr1 attenuate atherosclerosis in mice whereas NOR-1 aggravates vascular lesion formation.These exciting, novel insights on the function of NR4A nuclear receptors in immunity, vascular cells and atherosclerosis will initiate a plethora of studies to understand the underlying molecular mechanisms, which will culminate in the identification of novel NR4A targets to modulate chronic inflammatory disease.