High-Dose Naproxen Aggravates Pancreatic Fibrosis in a Rat Model of Chronic Pancreatitis

• DOI: 10.1097/mpa.0b013e3181bb90b5
• Publication Date: 2010-03-19T08:48:12Z
• Authors: Wei Zhang; Jun Gao; Tao Zhao; Wenbin Wu; Yu Bai; Duowu Zou; Zhaoshen Li
• Keywords: Hydroxyproline

: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for the treatment of pain in chronic pancreatitis (CP). This study aimed to investigate effect NSAIDs on inflammation and fibrosis progression trinitrobenzene sulfonic acid-induced CP rats.Chronic was induced by acid infusion into rat pancreatic ducts. Naproxen (20 40 mg/kg per os [PO] intraperitoneally) started 2 weeks after induction 3 weeks. Histological analysis pancreas, Van Gieson staining, contents hydroxyproline were used evaluate damage fibrosis. Furthermore, naproxen nociceptive reflective behaviors serum tumor necrosis factor alpha concentration studied, immunohistochemical alpha-smooth muscle actin pancreas performed.Pancreatic collagen content expression higher group treated with high-dose (40 PO) (P < 0.05). High-dose administered orally aggravated Instead playing an analgesic role, decreased thermal withdrawal latencies rats 0.05).High-dose played algogenic role that suggests potential risk long-term use as clinical practice CP.