Effects of Caspase-9 and Survivin Gene Polymorphisms in Pancreatic Cancer Risk and Tumor Characteristics

• DOI: 10.1097/mpa.0b013e3181d705d4
• Publication Date: 2010-03-31T09:56:10Z
• Authors: George E. Theodor...; Nikolaos V. Micha...; Sotirios-George P...; Styliani Taka; Maria Gazouli
• Keywords: Male; 0301 basic medicine; Polymorphism, Genetic; Genotype; Survivin; 610; Caspase 9; Inhibitor of Apoptosis Proteins; 3. Good health; Pancreatic Neoplasms; 03 medical and health sciences; Gene Frequency; Case-Control Studies; Humans; Female; Genetic Predisposition to Disease; Microtubule-Associated Proteins; Aged

This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer.Eighty patients with pancreatic cancer and 160 healthy controls were investigated for genotype and allelic frequencies of caspase-9 1263A/G and survivin -31G/C polymorphisms by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism.The G carrier group of patients and the G allele of caspase-9 1263A/G were overrepresented among the pancreatic cancer cases. With regard to tumor characteristics, a statistically significant association was detected between the survivin C carrier group of patients and the advanced T stage as well as the presence of lymph node metastasis.The caspase-9 G allele confers increased susceptibility to pancreatic cancer development, and the survivin C carriage status may be related to aggressive features of this malignancy.