Overexpression of FOXM1 Is Associated With Poor Prognosis and Clinicopathologic Stage of Pancreatic Ductal Adenocarcinoma

• DOI: 10.1097/mpa.0b013e31823bcef2
• Publication Date: 2012-01-13T09:05:05Z
• Authors: Jin-Tang Xia; Hua Wang; Li-Jian Liang; Bao-Gang Peng; Zhao-Feng Wu; Lian-Zhou Chen; Ling Xue; Zhi Li; Wen Li
• Keywords: FOXM1; Immunostaining

Oncogenic transcription factor forkhead box M1 (FoxM1)-related clinicopathologic characteristics and prognosis of patients with pancreatic ductal adenocarcinoma (PDA) have not been identified. Our aim studying FoxM1 expression level survival rate PDA is to determine whether a valuable prognostic predictor for patients.Expressional levels mRNA protein in paired cancer lesions adjacent noncancerous tissues were examined by reverse transcription-polymerase chain reaction Western blotting. was analyzed immunohistochemistry 80 PDA. The correlations between immunostaining factors, as well the follow-up data patients, statistically.FoxM1 elevated carcinoma compared tissues. A high significantly correlated clinical staging (P = 0.004), lymph node metastasis 0.009), histological differentiation 0.017). Patients higher had shorter time than those lower < 0.001). multivariate analysis revealed that could serve an independent poor prognosis.Our finding indicates be used molecular marker therapeutic target