Sarcopenia in Children With End‐Stage Liver Disease

• DOI: 10.1097/mpg.0000000000001792
• Publication Date: 2017-10-26T22:56:32Z
• Authors: Eberhard Lurz; Hiten Patel; Richard G. Frimpong; Amanda Ricciuto; Mohit Kehar; Paul W. Wales; Alexander J. Towbin; Govind B. Chavhan; Binita M. Kamath; Vicky L. Ng
• Keywords: Interquartile range; Liver disease; Body surface area

Sarcopenia, reflected by decreased psoas muscle surface area (PMSA), has been identified as a novel and independent predictor of wait-list mortality outcomes in adult liver transplantation (LT). We hypothesized that children with end-stage disease (ESLD) would have smaller PMSA than healthy controls.Computer tomography images (ages 0 to 18 years) listed for LT 2015 control group comprised 2:1 age- gender-matched pediatric trauma victims were reviewed. was determined at 2 intervertebral disc (L3/4; L4/5) levels. A subset reviewed radiologists determine interrater correlation.A total 23 ESLD included, the most prevalent diagnosis biliary atresia (61%). On both lumbar levels, median significantly subjects compared 46 controls (L4/5; (tPMSA) 407 mm (interquartile range 339-537) versus 513 437-672); P = 0.004), participants' weight z scores (r 0.01; 0.95). Excellent correlation seen (intraclass 0.99).In this retrospective pilot study, lower controls. Because finding growth subjects, may represent objective nutritional biomarker advanced disease.