Increased Mucosal Expression of Toll‐like Receptor (TLR)2 and TLR4 in Coeliac Disease

• DOI: 10.1097/mpg.0b013e318064514a
• Publication Date: 2007-07-24T08:03:14Z
• Authors: Beáta Szebeni; Gábor Veres; Antal Dezsőfi; Krisztina Rusai; Ádám Vannay; Géza Bokodi; Barna Vásárhelyi; IR Korponay‐Szabó; Tivadar Tulassay; András Arató
• Keywords: TLR3; Intestinal mucosa

The dysregulation of adaptive immunity is extensively investigated in celiac disease (CD). Recent data also suggest, however, the implication innate CD. Toll-like receptors (TLRs) play a central role initiation or maintenance immune responses. aim this study was to characterise expression TLR2, TLR3, and TLR4 duodenal biopsy samples taken from children with CD controls.Duodenal specimens were collected 16 untreated CD, 9 treated 10 controls. mRNA determined by semiquantitative reverse transcription-polymerase chain reaction. Protein levels TLRs Western blot.We found higher TLR2 protein mucosa compared even than TLR3 increased We able detect only patients CD.The alteration supports potential system pathomechanism disease.