Feasibility of Video Capsule Endoscopy in the Management of Children With Peutz‐Jeghers Syndrome: A Blinded Comparison With Barium Enterography for the Detection of Small Bowel Polyps

• DOI: 10.1097/mpg.0b013e31818f0a1f
• Publication Date: 2009-09-23T13:12:57Z
• Authors: Aymer Postgate; Warren Hyer; Robin Phillips; Arun Gupta; David Burling; Clive Bartram; Michelle Marshall; Stuart Taylor; Gregor Brown; Gill Schofield; Paul Bassett; Christine Spray; Aine Fitzpatrick; Chris Fraser; A Latchford
• Keywords: Peutz–Jeghers syndrome; Interquartile range; Polypectomy; Enteroscopy

Peutz-Jeghers syndrome (PJS) in children may present with anaemia, intussusception, or obstruction from an early age and surgery is common. Prophylactic polypectomy reduce subsequent complications. Traditional barium enterography (BE) has poor sensitivity requires significant radiation. We compared the performance of capsule endoscopy (CE) BE PJS.Children PJS (ages 6.0-16.5 years) were prospectively recruited underwent followed by CE, each reported expert reviewers blinded to alternate modality. Number "significant" (>10 mm) total number polyps recorded. Child preference was assessed using a visual analogue questionnaire. Definitive findings at laparotomy enteroscopy, when performed.There no difference for >10 mm polyp detection. Six found 3 both modalities: 2 1 child (P=0.50). Re-review CE identified that missed initial reading. Significantly more <10 than BE: 61 vs 6 (P=0.02). significantly comfortable (median score 76 [interquartile range 69-87] 37 31-68], P=0.03) preferred investigation 90% (P=0.02).CE feasible, safe, sensitive test small bowel surveillance PJS. It most future surveillance. There learning curve reporting studies appropriate training essential.