Cow's Milk Allergy, Asthma, and Pediatric IBD

Male 0301 basic medicine 0303 health sciences Adolescent Infant Inflammatory Bowel Diseases Asthma 3. Good health 03 medical and health sciences Crohn Disease Risk Factors Case-Control Studies Child, Preschool Odds Ratio Humans Colitis, Ulcerative Female Registries Milk Hypersensitivity Child Finland
DOI: 10.1097/mpg.0b013e318285e9d8 Publication Date: 2013-01-12T10:46:16Z
ABSTRACT
ABSTRACTWe identified a total of 595 Finnish children born in 1994–2008 and diagnosed as having inflammatory bowel disease (IBD) by October 2010 from the National Reimbursement Register (based on certificates including the diagnostic criteria) to determine whether the presence of cow's milk allergy (CMA) or asthma is associated with the risk of contracting IBD (altogether 2380 matched controls). A diagnosis of CMA in infancy was associated with Crohn disease (odds ratio [OR] 1.92, confidence interval [CI] 1.09–3.36, P < 0.05) and ulcerative colitis (OR 1.71, CI 1.04–2.83, P < 0.05), but childhood asthma only with Crohn disease (OR 2.33, CI 1.41–3.86, P = 0.001). Thus, CMA in infants is a risk factor for contracting pediatric IBD and accordingly, asthma for Crohn disease.
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