Vincristine-induced Peripheral Neuropathy and Urinary Bladder Paralysis in a Child With Rhabdomyosarcoma

• DOI: 10.1097/mph.0b013e318158343b
• Publication Date: 2009-03-05T05:40:45Z
• Authors: Elvan Caglar Citak; Aynur Oguz; Ceyda Karadeniz; Belgin Karaoglan; Mustafa Ozgur Tan; Visal Okur; Ali Cansu
• Keywords: Male; Electromyography; 3. Good health; Urodynamics; 03 medical and health sciences; 0302 clinical medicine; Vincristine; Antineoplastic Combined Chemotherapy Protocols; Rhabdomyosarcoma; Dactinomycin; Humans; Paralysis; Urinary Bladder, Neurogenic; Child; Cyclophosphamide; Monitoring, Physiologic

Vincristine commonly induces peripheral neuropathy but rarely causes voiding dysfunction. In this report, we describe a case of neurogenic bladder and peripheral neuropathy caused by the neurotoxic effect of vincristine and documented by urodynamic testing and electromyography. Neurologic evaluation aided in monitoring and understanding this problem.