Pediatric Hodgkin Lymphoma in 2 South American Series: A Distinctive Epidemiologic Pattern and Lack of Association of Epstein-Barr Virus With Clinical Outcome

• DOI: 10.1097/mph.0b013e3181647bc3
• Publication Date: 2009-03-03T22:23:34Z
• Authors: Paola A. Chabay; Mário H. M. Barros; Rocío Hassan; Elena De Matteo; Guadalupe Rey; Maria Kadma Carrico; Ilana Zalcberg Re...; María Victoria Pr...
• Keywords: Nodular sclerosis; Epstein–Barr virus infection; Clinical Significance

Hodgkin lymphoma (HL) shows a bimodal distribution with first peak in developing countries during childhood. The causative role and prognostic significance of Epstein-Barr virus (EBV) association patients HL is controversial. Our aim was to perform comparative study EBV 2 Latin American pediatric series, correlate it patient's survival. encoded RNAs situ hybridization latent membrane protein 1 immunohistochemistry were performed on formalin-fixed, paraffin-embedded biopsies from 176 public institutions Argentina Southeast Brazil. Mixed cellularity subtype prevalent Argentine (Arg HL) (52%) nodular sclerosis Brazilian (BR (83%). expression detected 52% cases, namely 54% Arg 48% Br HL. significantly associated mixed both populations. In HL, positivity higher patients<or=10 years (P=0.0011). Event-free survival did not attain statistical neither (P=0.5317), nor (P=0.8321). results do support stated for countries. Correlation younger age infection only might be related different background. our status cannot used as factor.