Kasabach-Merritt Phenomenon

Male Infant, Newborn Infant Kasabach-Merritt Syndrome Combined Modality Therapy 3. Good health 03 medical and health sciences Treatment Outcome 0302 clinical medicine Humans Female Retrospective Studies
DOI: 10.1097/mph.0b013e318281558e Publication Date: 2013-02-06T15:16:45Z
ABSTRACT
Kasabach-Merritt phenomenon (KMP) is a rare condition and optimal treatments have not yet been established, especially for cases that are unresponsive to first-line therapy. We retrospectively reviewed 11 KMP cases treated over the past 13 years in our institute.With the exception of 1 case, steroids were administered as the first-line therapy. Eight cases required second-line or third-line therapy. The effective salvage therapies include interferon (n=1), radiotherapy (n=1), and chemotherapy (n=5). One case continues to depend upon chemotherapy. Three refractory cases were therapy dependent over 1 year of age, whereas 8 were treated effectively by 6 months of age.Chemotherapy seems to be the most effective therapy for steroid-resistant KMP cases.
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