Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb

• DOI: 10.1097/nen.0b013e31818b4126
• Publication Date: 2008-10-28T07:09:27Z
• Authors: Renpei Sengoku; Yuko Saito; Masako Ikemura; Hiroyuki Hatsuta; Yoshio Sakiyama; Kazutomi Kanemaru; Tomio Arai; Motoji Sawabe; Noriko Tanaka; Hideki Mochizuki; Kiyoharu Inoue; Shigeo Murayama
• Keywords: Aged, 80 and over; Male; Aging; Amyloid beta-Peptides; Tyrosine 3-Monooxygenase; Ubiquitin; Incidence; Statistics as Topic; Brain; tau Proteins; Olfactory Bulb; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Spinal Cord; Serine; alpha-Synuclein; Humans; Female; Lewy Bodies; Mental Status Schedule; Aged

We investigated the incidence and extent of Lewy body (LB)-related α-synucleinopathy (LBAS) in olfactory bulb (OB) 320 consecutive autopsy patients from a general geriatric hospital (mean age, 81.5 ± 8.5 years). Paraffin sections were immunostained with anti-phosphorylated α-synuclein, tyrosine hydroxylase, phosphorylated tau, amyloid β antibodies. LBAS was found 102 (31.9%) central nervous system, including spinal cord; OB involved 85 (26.6%). Among these patients, 2 had only anterior nucleus, 14 peripheral only, 69 both areas. In 5 bodies by hematoxylin eosin stain; 3 Alzheimer disease, all LBAS. Very few hydroxylase-immunoreactive periglomerular cells exhibited All 35 pigmentation loss substantia nigra OB. amygdala more strongly correlated nucleus than that periphery. did not correlate systemic tauopathy or amyloidosis. These results indicate high aging human OB; they also suggest extends periphery to clinical manifestations LB disease.