Alterations of the Microvascular Network in Sclerotic Hippocampi From Patients With Epilepsy

• DOI: 10.1097/nen.0b013e3181b08622
• Publication Date: 2009-07-24T07:35:09Z
• Authors: Asta Kastanauskaite; Lidia Alonso-Nanc...; Lidia Blazquez-Ll...; Jesus Pastor; Rafael G. Sola; Javier DeFelipe
• Keywords: Adult; Male; Neurons; Electron Microscope Tomography; Epilepsy; Sclerosis; Adolescent; Cell Count; Middle Aged; Hippocampus; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Microvessels; Humans; Female; Nerve Net; Aged

The main hallmarks of human hippocampal sclerosis are neuronal loss and gliosis; reductions in microvasculature labeling the cornu Ammonis 1 this condition have been detected using alkaline phosphatase histochemistry. To determine whether reduction inalkaline activity is coupled with a blood vessels,we examined volume fraction occupied by vessels toluidine blue-stained sections from 24 epilepsy patientresections (19 sclerosis, 5 without sclerosis) normal autopsy controls. Light electron microscopy immunohistochemistry were used to distribution collagen Type IV relation fine structure microvascular network. We found consistent highly significant microvessels sclerotic field; variety vascular alterations including spinelike protrusions, disruptions, atrophic branching, observed remaining vessels. suggest that vessel an additional pathological hallmark associated temporal lobe they may relate pathogenesis condition.