Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease

• DOI: 10.1097/nen.0b013e3182632566
• Publication Date: 2012-07-17T10:24:45Z
• Authors: Akihiko Hoshi; Teiji Yamamoto; Keiko Shimizu; Yoshikazu Ugawa; Masatoyo Nishizawa; Hitoshi Takahashi; Akiyoshi Kakita
• Keywords: Aquaporin 4; Angiopathy; Amyloid (mycology)

Senile plaques (SPs) containing amyloid β peptide (Aβ) 1-42 are the major species present in Alzheimer disease (AD), whereas Aβ1-40 is constituent of arteriolar walls affected by cerebral angiopathy. The water channel proteins astrocytic aquaporin 1 (AQP1) and 4 (AQP4) known to be abnormally expressed AD brains, but expression AQPs surrounding SPs angiopathy has not been described detail. Here, we investigated whether AQP associated with each Aβ deposited human brains either sporadic or familial AD. Immunohistochemical analysis demonstrated more numerous AQP1-positive reactive astrocytes cortex than controls, located close Aβ42- Aβ40-positive SPs. In cases, however, were often observed Aβ-rich areas, there was a significant negative correlation between levels AQP1 Aβ42 assessed semiquantitatively. We also found that plaque-like AQP4 distributed association degree around vessels variable. These findings suggest defined population may modify deposition brain, process might alter AQP4.