Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis

• DOI: 10.1097/nen.0b013e31827fd9e8
• Publication Date: 2013-01-18T08:12:40Z
• Authors: Debbie A.E. Hendr...; Nathalie Koning; Karianne G. Schuu...; Miriam E. van Strien; Corbert G. van Eden; Jörg Hamann; Inge Huitinga
• Keywords: Scavenger Receptor; CD68; CXCL16; Demyelinating disease

Autoantibodies and complement opsonization have been implicated in the process of demyelination major human CNS demyelinating disease multiple sclerosis (MS), but scavenger receptors (SRs) may also play pathogenetic roles. We characterized SR mRNA protein expression postmortem brain tissue from 13 MS patients relation to active demyelination. CD68, chemokine (C-X-C motif) ligand 16 (CXCL16), class A macrophage SR(SR-AI/II), LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1), FcγRIII, LRP-1 (low-density receptor-related 1) were upregulated rims chronic lesions. CD68 CXCL16 around By immunohistochemistry, CXCL16, SR-AI/II expressed by foamy macrophages rim ramified microglia astrocytes lesions primary vitro. These data suggest that SRs are involved myelin uptake MS, upregulation is one initial events as they initiate phagocytosis. As continues, additional LOX-1, facilitate this process.