Treponema pallidum Azithromycin Resistance in Dublin, Ireland

• DOI: 10.1097/olq.0b013e318269995f
• Publication Date: 2013-01-03T03:19:08Z
• Authors: Eavan G. Muldoon; Anne Walsh; Brendan Crowley; Fiona Mulcahy
• Keywords: Adult; DNA, Bacterial; Male; Azithromycin; Middle Aged; Anti-Bacterial Agents; 3. Good health; RNA, Ribosomal, 23S; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Drug Resistance, Bacterial; Mutation; Humans; Female; Syphilis; Treponema pallidum; Ireland

This study aimed to reassess rates of syphilis azithromycin resistance in Dublin. Of the 104 samples, 36 (34.6%) were positive for Treponema pallidum DNA by polymerase chain reaction. Thirty samples were analyzed for A2058G mutation, 29 samples sequenced. Of the 29 samples, 27 (93.1%) had the mutation. Azithromycin cannot be recommended for the treatment of syphilis in Dublin.