A High Number of CD8+ T Cells Infiltrated in NSCLC Tissues is Associated With a Favorable Prognosis

• DOI: 10.1097/pai.0b013e3181b6a741
• Publication Date: 2009-12-15T08:32:57Z
• Authors: Xuewei Zhuang; Xiyan Xia; Chuanxin Wang; Fei Gao; Ningning Shan; Lei Zhang; Lining Zhang
• Keywords: Tumor-infiltrating lymphocytes

We investigated the number of intratumoral tumor-infiltrating lymphocytes (TILs), including CD4(+), CD8(+), and CD25(+) T cells, in nonsmall cell lung cancers (NSCLC) their correlation with patient survival time. Tumor specimens from 30 NSCLC patients were consecutively obtained during surgery. Patient status was monitored. Based on time, divided into 2 groups: 5-year group nonsurvival group. cells that infiltrated tumors detected counted by immunohistochemistry. Patients a lower TILs CD8(+) showed significantly shorter time compared those higher (P < 0.05). However, CD4(+) not correlated > These data demonstrate high numbers among is strong indicator for favorable clinical outcome.