Combination of Napsin A and TTF-1 Immunohistochemistry Helps in Differentiating Primary Lung Adenocarcinoma From Metastatic Carcinoma in the Lung

• DOI: 10.1097/pai.0b013e318205b059
• Publication Date: 2011-04-05T04:17:58Z
• Authors: Jiqing Ye; Jennifer J. Finde...; Qi Yang; Loralee A. McMahon; Jorge L. Yao; Faqian Li; Haodong Xu
• Keywords: Immunostaining

Differentiation of primary from metastatic adenocarcinoma in the lung can be challenging, and it demands sensitive specific biomarkers, especially when tissue for diagnosis is limited. Thyroid transcription factor-1 (TTF-1) has been considered a reliable marker origin. However, several recent studies have shown that TTF-1 immunostaining also positive adenocarcinomas arising different organs including colon, endometrium, endocervix, ovary. In addition, approximately 20% are negative immunostaining, napsin A slightly higher sensitivity detecting adenocarcinoma. We performed on 120 cases 37 carcinomas lung. The results showed 95 (79.2%) A(+)/TTF-1(+) double-positive pattern. TTF-1(−)/napsin A(+), TTF-1(+)/napsin A(−), A(−) were seen 8.3%, 3.3%, 9.2% adenocarcinomas, respectively. Eight (21.6%) they include clear-cell renal cell completely although was detected 12 (80.0%) 15 papillary 3 (33.3%) 9 carcinomas. All epithelial neoplasms negative. These findings indicate double TTF-1-positive highly combination these 2 biomarkers warranted to help segregating carcinoma