Neurothekeoma and Plexiform Fibrohistiocytic Tumor

• DOI: 10.1097/pas.0b013e31819c79f7
• Publication Date: 2009-05-21T10:05:20Z
• Authors: Shabnam Jaffer; Andrea Ambrosini-...; Antonio M. Mancini; Vincenzo Eusebi; Juan Rosai
• Keywords: Histogenesis; CD68

Neurothekeoma (NTK) and plexiform fibrohistiocytic tumor (PFHT) are dermal neoplasms that share many clinical histologic features whose histogenesis is equally disputed. We analyzed the morphologic immunohistochemical of 43 NTK 18 PFHT to evaluate a possible relationship between these tumors. On basis amount myxoid stroma, we divided into neurothekeoma (MyNTK) (8 cases), mixed (MiNTK) (15 cellular (CNTK) (20 cases). MyNTK MiNTK were well circumscribed lesions composed spindle cells. CNTK had an infiltrative quality consisted predominantly epithelioid cells, with over 50% cases containing multinucleated giant cells in 11 cases, 1, even admixture 6 cases. Their (particularly those more examples) superimposable CNTK. Immunohistochemically, there was positivity for S100 protein 8 MyNTK, 4 15 MiNTK, 1 19 CNTK, 0 PFHT. There CD68 9 17 These results suggest existence continuum MiNTK. Furthermore, marked phenotypic similarities common 2 tumors, different from