Nonhepatosplenic γδ T-cell Lymphomas Represent a Spectrum of Aggressive Cytotoxic T-cell Lymphomas With a Mainly Extranodal Presentation
T-Cell Lymphoma
Gene rearrangement
Peripheral T-cell lymphoma
DOI:
10.1097/pas.0b013e31822067d1
Publication Date:
2011-07-13T15:34:06Z
AUTHORS (19)
ABSTRACT
γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these have been recognized: hepatosplenic lymphoma (HSTL) and primary cutaneous (PCGD-TCL). However, whether other anatomic sites may also be involved they spectrum of the same disease are not well studied. The lack receptor (TCR)β expression has used to infer origin when methods available. We studied 35 tumors suspected TCL using monoclonal antibodies reactive with TCR δ or γ paraffin sections. were able confirm chain 22 cases. identified 8 PCGD-TCLs, 6 HSTLs, TCLs without involvement involving extranodal sites. such cases classified as enteropathy-associated lymphoma, type II. presented intestine, lung, tongue, orbit, lymph node. In addition, we observed 13 lacked any ("TCR silent"). all cases, natural killer cell was excluded. conclusion, TCRβ does always predict γδ-T-cell derivation, silent found. recognition presenting than skin liver/spleen expands clinical tumors. non-HSTL do seem single entity. relationship either HSTL PCGD-TCL requires further study.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (0)
CITATIONS (118)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....