Nonhepatosplenic γδ T-cell Lymphomas Represent a Spectrum of Aggressive Cytotoxic T-cell Lymphomas With a Mainly Extranodal Presentation

• DOI: 10.1097/pas.0b013e31822067d1
• Publication Date: 2011-07-13T15:34:06Z
• Authors: Adriana Garcia-He...; Joo Y. Song; Shih-Sung Chuang; Neus Villamor; Luis Colomo; Stefania Pittaluga; Tomas Alvaro; Maria Rozman; Jazmin de Anda Go...; Ana Maria Arrunat...; Eva Fernandez; Elena Gonzalvo; Teresa Estrach; Dolors Colomer; Mark Raffeld; Philippe Gaulard; Elias Campo; Elaine S. Jaffe; Antonio Martinez
• Keywords: T-Cell Lymphoma; Gene rearrangement; Peripheral T-cell lymphoma

γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these have been recognized: hepatosplenic lymphoma (HSTL) and primary cutaneous (PCGD-TCL). However, whether other anatomic sites may also be involved they spectrum of the same disease are not well studied. The lack receptor (TCR)β expression has used to infer origin when methods available. We studied 35 tumors suspected TCL using monoclonal antibodies reactive with TCR δ or γ paraffin sections. were able confirm chain 22 cases. identified 8 PCGD-TCLs, 6 HSTLs, TCLs without involvement involving extranodal sites. such cases classified as enteropathy-associated lymphoma, type II. presented intestine, lung, tongue, orbit, lymph node. In addition, we observed 13 lacked any ("TCR silent"). all cases, natural killer cell was excluded. conclusion, TCRβ does always predict γδ-T-cell derivation, silent found. recognition presenting than skin liver/spleen expands clinical tumors. non-HSTL do seem single entity. relationship either HSTL PCGD-TCL requires further study.