Grading of Clear Cell Renal Cell Carcinoma Should be Based on Nucleolar Prominence

• DOI: 10.1097/pas.0b013e318220697f
• Publication Date: 2011-06-30T18:23:52Z
• Authors: Brett Delahunt; Dianne Sika-Paotonu; Peter B. Bethwaite; Thomas William Jo...; Cristina Magi-Gal...; Ming Zhou; Hemamali Samaratunga; John R. Srigley
• Keywords: Grading (engineering)

Fuhrman grading of renal cell carcinoma focuses on features nuclear size, shape, and nucleolar prominence. Despite the reported widespread usage in clinical studies, there is debate as to prognostic significance reproducibility its criteria. It has been noted that many pathologists rely assessment prominence alone when carcinoma; however, validity this remains unconfirmed. This study was undertaken determine relationship 3 morphologic components system with one another which, if any these, can be correlated outcome for clear carcinoma. One hundred twenty-one organ-confined carcinomas were examined study. Parameters size (area, major axis, perimeter) shape (shape factor, compactness) assessed by image analysis, whereas assigned (grades 1 3) using criteria Fuhrman. On basis predominant grade present, 17 1, 90 2, 14 tumors. When high-power field each tumor worst assessed, 68 52 Predominant all measures but not shape. Worst parameters significantly associated outcome. multivariate retained a significant association survival modeled area. Neither nor axis/nuclear perimeter together. In study, we have shown are We further independent area, it dependent variable tested against other size. These findings indicate valid parameter