Ovarian Endometrioid Adenocarcinoma

• DOI: 10.1097/pas.0b013e31823bc434
• Publication Date: 2011-12-21T10:13:31Z
• Authors: Anil Aysal; Anthony Karnezis; Irum Medhi; James P. Grenert; Charles J. Zaloudek; Joseph T. Rabban
• Keywords: Lynch Syndrome; Microsatellite Instability; MSH2; MSH6; PMS2; MLH1; Uterine cancer

A subset of women with uterine cancer exhibiting defective mismatch repair (MMR) proteins and microsatellite instability (MSI) may have Lynch syndrome, which also confers a risk for colorectal other cancers in the patient her family. Screening algorithms based on clinical pathologic criteria are effective determining patients most likely to benefit from definitive genetic testing syndrome. Ovarian cancer, particularly endometrioid adenocarcinoma, is associated although much smaller than cancer. This study evaluated whether morphologic [tumor-infiltrating lymphocytes (TILs), peritumoral (PTLs), dedifferentiated morphology)] currently used screen further syndrome can be applied ovarian Among 71 pure adenocarcinoma treated at single institution, 13% had tumor TILs, 3% PTLs, none morphology. Overall, 10% tumors abnormal MMR protein status, defined as complete immunohistochemical loss expression MLH1, MSH2, MSH6, and/or PMS2. Each these status demonstrated MSI using polymerase chain reaction-based assay evaluating 5 mononucleotide repeat markers. No relationship was found between age, or spectrum variables status/MSI. Only 1/7 MMR/MSI TILs/PTLs. 14 who died, 12 (86%) normal status. 7 MMR/MSI, (71%) were alive without disease. Concurrent present 5/7 whose MMR/MSI. suggests that not applicable Although did carry prognostic value this study, it predict involvement uterus by tumor. Thus, undergo uterus-sparing surgery, should prompt diagnostic evaluation endometrium