Extranodal NK/T-cell Lymphoma, Nasal Type, Arising in Association With Saline Breast Implant

• DOI: 10.1097/pas.0b013e31826a006f
• Publication Date: 2012-10-16T10:25:37Z
• Authors: Tariq N. Aladily; Bharat N. Nathwani; Roberto N. Miranda; Rina Kansal; C. Cameron Yin; Richard Protzel; Gary S. Takowsky; L. Jeffrey Medeiros
• Keywords: Anaplastic large-cell lymphoma; T-Cell Lymphoma; Immunophenotyping; Breast implant; CD5

Extranodal NK/T-cell lymphoma, nasal type, is a rare type of non-Hodgkin lymphoma that most common in Asia and driven by Epstein-Barr virus infection. These tumors usually arise the region; cases they can involve extranasal sites, often skin, with involvement breast being rare. Lymphomas arising adjacent to implants are rare, reported date have been anaplastic kinase (ALK)-negative large cell lymphoma. Here we report 41-year-old white woman bilateral saline placed for cosmetic reasons who almost 9 years later developed painful swelling at right-breast implant site. Excisional biopsy revealed composed monomorphic cells associated necrosis angioinvasion. Immunohistochemical analysis showed an aberrant, immunophenotype CD2+, CD3+, CD56+, partial CD30+, granzyme B, TIA-1+, CD4+, CD5+, CD7+, CD8+. In situ hybridization virus-encoded RNA within neoplastic cells. Polymerase chain reaction monoclonal T-cell receptor-γ gene rearrangement. findings support diagnosis extranodal type. On basis our review literature, this case unique. addition, believe important report, because it expands spectrum lymphomas be may forerunner additional follow.