Transitional Cell-like Morphology in Ovarian Endometrioid Carcinoma

• DOI: 10.1097/pas.0b013e31826a5399
• Publication Date: 2012-10-30T08:47:59Z
• Authors: Anthony N. Karnezis; Anil Aysal; Charles J. Zaloudek; Joseph T. Rabban
• Keywords: Serous carcinoma; Transitional Cell; Clear cell carcinoma

Transitional cell-like growth has been reported as a morphologic variant of endometrioid adenocarcinoma in the uterus but is not well-described ovary. We report clinicopathologic features series ovarian adenocarcinomas with transitional morphology, emphasizing distinction from its mimics, including high-grade serous carcinoma, cell and granulosa tumor. Among cohort 71 surgically staged at our institution, 10 tumors (14%) exhibited morphology. Patient age ranged 39 to 79 years (mean, 52 y). Five were stage I, 2 II, 3 III. The 8.5 23 cm, component occupied 5% 90% overall tumor, remainder being conventional adenocarcinoma. most compelling findings support that this tumor pattern represents are components (1) merged directly seamlessly component; (2) contained areas mature or immature squamous differentiation; (3) lacked WT1 immunoexpression; (4) characteristic p53/p16 immunophenotype carcinoma; (5) did appear independently affect patient outcome. Two patients (20%) whose morphology died, whereas 14 (23%) lacking died. Although uncommon, appears be does behavior should distinguished carcinoma carcinoma.