Distinctive Histopathologic Findings of Pancreatic Hamartomas Suggesting Their “Hamartomatous” Nature

• DOI: 10.1097/pas.0b013e318283ce4c
• Publication Date: 2013-05-25T12:06:15Z
• Authors: Hiroshi Yamaguchi; Shinichi Aishima; Yoshinao Oda; Hiroki Mizukami; Takuma Tajiri; Sohsuke Yamada; Takashi Tasaki; Keisuke Yamakita; Koji Imai; Fumi Kawakami; Shigeo Hara; Keiji Hanada; Tomohiro Iiboshi; Toshikatsu Fukuda; Hiroshi Imai; Hiroyuki Inoue; Tatsuya Nagakawa; Shunji Muraoka; Toru Furukawa; Michio Shimizu
• Keywords: Hamartoma; Autoimmune Pancreatitis

Pancreatic hamartoma is a rare tumor, and its characteristic histopathologic features have not yet been fully evaluated. In this study, we collected 9 cases of pancreatic to elucidate distinctive that can serve establish tumor as clear disease entity thus formulate useful criteria for tumor. The comprised 4 men 5 women with mean age 62.7 years. average diameter was 3.3 cm. All patients underwent surgical treatment, none showed any recurrence postoperatively. Macroscopically, hamartomas were well-demarcated tumors solid or cystic appearance. Microscopically, these mature acini small-sized medium-sized ducts showing distorted architecture various amounts fibrous stroma. Strikingly, the consistently lacked concentric elastic fibers in their duct walls, peripheral nerves, well-formed islets Langerhans, all which exist both normal atrophic pancreas. Immunohistochemically, scattered chromogranin A-positive neuroendocrine cells observed acinar ductal components. Ductal components positive S-100 protein. Spindle-shaped stromal expressed CD34 and/or c-kit. These distinct from those adenocarcinoma, 3 type 1 autoimmune pancreatitis (lymphoplasmacytic sclerosing pancreatitis), alcoholic chronic pancreatitis, conclusion, share some clinical outcomes (neither nor metastasis) allow them be interpreted malformative lesions. term "hamartoma" appropriate unique