High mortality in patients with influenza A pH1N1 2009 admitted to a pediatric intensive care unit

• DOI: 10.1097/pcc.0b013e318219266b
• Publication Date: 2011-05-06T08:43:47Z
• Authors: Silvio Fabio Torres; Thomas Iolster; Eduardo Julio Sch...; Julio Alberto Farias; Adriana Claudia B...; Daniel Rufach; María José Montes; Alejandro Javier ...; María Gabriela Ro...; Roberto Jabornisky; Carmen Colman; Analia Fernández; Gustavo Caprotta; Silvia Diaz; Roxana Poterala; Marcela De Meyer; Matías Enrique Pe...; Gustavo González; Silvia Saenz; Oscar Recupero; Luis Zapico; Blanca Alarcon; Esen Ariel; Pablo Minces; Eduardo Mari; Antonio Carnie; Mónica Garea; Roxana Jaen
• Keywords: Male; Models, Statistical; Argentina; Infant; Intensive Care Units, Pediatric; Respiration, Artificial; 3. Good health; 03 medical and health sciences; Influenza A Virus, H1N1 Subtype; Treatment Outcome; 0302 clinical medicine; Risk Factors; Child, Preschool; Influenza, Human; Humans; Female; Hospital Mortality; Retrospective Studies

To describe the clinical characteristics and outcome of patients admitted to pediatric intensive care with influenza A (pH1N1) 2009 in Argentina.Retrospective observational study.Thirteen units Argentina.One hundred forty-two confirmed or suspected (H1N1).None.We included 142 critically ill patients. The median age was 19 months (range, 2-110 months) 39% <24 age. Ninety-nine (70%) had an underlying disease. Influenza infection 90 remaining 52 a positive direct immunofluorescence assay for A. length stay unit 12 days 2-52 days). One eighteen (83%) received invasive mechanical ventilation were treated noninvasive ventilation; however, seven receiving later needed ventilation. Sixty-eight died (47%) most frequent cause refractory hypoxemia. Multivariate logistic regression analysis showed that (odds ratio, 2.87; 2.35-3.93), asthma 1.34; 1.20-2.91), respiratory coinfection syncytial virus 2.92; 1.20-4.10) associated higher mortality. As expected, treatment inotropes also increased mortality.The mortality children pH1N1 high our population. Age months, asthma, coinfection, need ventilation, predictors poorer outcome.