Breast Cancer During Pregnancy

• DOI: 10.1097/ppo.0b013e3181ce46f9
• Publication Date: 2010-02-17T07:33:45Z
• Authors: Elyce Cardonick; Rebecca Dougherty; Generosa Grana; Dzhamlaa Gilmandyar; Sadia Ghaffar; Aniqa Usmani
• Keywords: Adult; Infant, Newborn; Pregnancy Outcome; Antineoplastic Agents; Breast Neoplasms; Gestational Age; Middle Aged; Combined Modality Therapy; 3. Good health; Survival Rate; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Risk Factors; Humans; Female; Prospective Studies; Registries; Neoplasm Recurrence, Local; Pregnancy Complications, Neoplastic; Follow-Up Studies; Neoplasm Staging

Breast cancer is the most common malignancy occurring during pregnancy. Because more women delay childbearing, diagnosis of pregnancy will likely increase. Case reports exist in literature regarding treatment pregnant with breast cancer, but few are prospective and provide long-term follow-up on neonate exposed to chemotherapy. In this report, 130 diagnosed were reported our voluntary national registry followed up prospectively.The Cancer Pregnancy Registry a that monitors clinical course, treatment, disease outcome perinatal neonatal outcomes their children.Of diagnosed, 120 primary tumor, 8 recurrence, 2 new cancer. Mean maternal age at was 34.8 +/- 4.2 years. gestational 13.2 8.1 weeks. Gestational 12.8 7.8 weeks for patients 16.25 11 those recurrent One hundred thirteen mean 3.14 2.5 Of up, 103 pregnancy, primary. Recurrence 30 an average 16.2 10.8 months from delivery recurrence. Twenty-one deceased 24.71 15.32 death. Only 42% estrogen-positive tumor 35% cases had progesterone receptor-positive tumor. Human epidermal growth factor receptor positive 25% patients. Chemotherapy given 104 cases; first 20.4 5.4 The malformation rate neonates 3 not greater than general population. Survival by stage as follows: I, 100%; II, 86%; III, IV, 0%.Pregnant can receive comparable nonpregnant leading similar survival when matched diagnosis. majority children who chemotherapy utero did demonstrate significant complications. We report single largest cohort