Once Is Not Enough

• DOI: 10.1097/prs.0b013e31825dbefe
• Publication Date: 2012-05-10T08:59:37Z
• Authors: John L. Clayton; Andrea Bazakas; Clara N. Lee; C. Scott Hultman; Eric G. Halvorson
• Keywords: Regimen; Surgical Site Infection

There has been a trend toward limiting perioperative prophylactic antibiotics, based on research not conducted in plastic surgery patients. The authors' university hospital instituted antibiotic prescribing guidelines the Surgical Care Improvement Project. An increased rate of surgical-site infections was noted breast reconstruction authors sought to determine whether change prophylaxis regimen affected rates infections.A retrospective study compared patients undergoing who received preoperative and postoperative antibiotics with group only single dose antibiotic. Type known risk factors for implant infection were noted.Two hundred fifty included: 116 pre-Surgical Project 134 group. overall from 18.1 percent 34.3 (p = 0.004). Infections requiring reoperation 4.3 16.4 0.002). Multivariate logistic regression demonstrated that 4.74 times more likely develop (95 CI, 1.69 13.80). Obesity, history radiation therapy, tissue expanders associated reoperation.Withholding prosthetic is an infection, reoperation, thus reconstructive failure. optimal duration use subject future study.