Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection

• DOI: 10.1097/qad.0b013e328012b8ac
• Publication Date: 2007-02-12T09:05:02Z
• Authors: Pierre-Yves Bochud; Martin Hersberger; Patrick Taffé; Murielle Bochud; Catherine M Stein; Stephanie D Rodri...; Thierry Calandra; Patrick Francioli; Amalio Telenti; Roberto F Speck; Alan Aderem
• Keywords: Linkage Disequilibrium

The clinical course of HIV-1 infection is highly variable among individuals, at least in part as a result genetic polymorphisms the host. Toll-like receptors (TLRs) have key role innate immunity and mutations genes encoding these been associated with increased or decreased susceptibility to infections.