High rate of extensively drug-resistant tuberculosis in Indian AIDS patients

• DOI: 10.1097/qad.0b013e3282f125c9
• Publication Date: 2009-03-03T23:35:52Z
• Authors: Sarman Singh; Manimuthu Mani Sa...; Krishnamoorthy Go...
• Keywords: Adult; Male; 0301 basic medicine; Acquired Immunodeficiency Syndrome; Extensively Drug-Resistant Tuberculosis; Sputum; India; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Middle Aged; 3. Good health; 03 medical and health sciences; Prevalence; Humans; Female; Lymphocyte Count

Fifty-four full-blown AIDS patients suspected of having HIV-tuberculosis co-infection were investigated for the prevalence of extensively drug-resistant (XDR) Mycobacterium tuberculosis. Out of the 54 patients, M. tuberculosis was isolated from 24 (44.4%). Twelve (50%) isolates of these had resistance to first-line drugs, whereas four (33.33%) were also resistant to second-line drugs. All four patients, in whom XDR M. tuberculosis was isolated, died within 2.6 months of diagnosis.