Potent immune responses of Ag-specific Vγ2Vδ2+ T cells and CD8+ T cells associated with latent stage of Mycobacterium tuberculosis coinfection in HIV-1-infected humans

• DOI: 10.1097/qad.0b013e3283117f18
• Publication Date: 2008-10-31T07:09:42Z
• Authors: Lingyun Shao; Wenhong Zhang; Shu Zhang; Crystal Y Chen; Weimin Jiang; Yunya Xu; Chengyan Meng; Xinhua Weng; Zheng W Chen
• Keywords: Adult; CD4-Positive T-Lymphocytes; Male; 0303 health sciences; AIDS-Related Opportunistic Infections; Fluorescent Antibody Technique; HIV Infections; Receptors, Antigen, T-Cell, gamma-delta; Mycobacterium tuberculosis; CD8-Positive T-Lymphocytes; Middle Aged; CD4 Lymphocyte Count; 3. Good health; 03 medical and health sciences; HIV-1; Humans; Female

To investigate immune responses of peptide-specific CD4+ and CD8+ T cells, nonpeptide-specific Vgamma2Vdelta2+ cells during clinical quiescence latent Mycobacterium tuberculosis coinfection in HIV-1-infected humans.One hundred individuals who had HIV infection only [HIV+tuberculosis-(TB-)], (HIV + LTB), or active TB) were recruited to measure mycobacterium purified protein derivative (PPD)-specific IFNgamma+ phosphoantigen HMBPP-specific using enzyme-linked immunospot intracellular cytokine staining assays.Both TB LTB groups low levels PPD-specific regardless peripheral blood lymphocytes counts. However, numbers the group significantly greater than those group. Surprisingly, hydroxy-3-methyl-but-2-enyl pyrophosphate-specific much (P < 0.001). This difference was present subgroups whatever T-cell counts more 200/microl less 200/microl. Numbers even five times CD8 within group.Potent detected persons but not patients. The robust effector associated with stage humans.