Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline

• DOI: 10.1097/qad.0b013e328341b84e
• Publication Date: 2010-11-20T10:01:48Z
• Authors: Norma I Rallon; Clara Restrepo; Susanna Naggie; Mariola Lopez; Jorge del Romero; David Goldstein; John McHutchison; Vincent Soriano; Jose M Benito
• Keywords: CD4-Positive T-Lymphocytes; Male; 0301 basic medicine; Interleukins; Viral Load; Polymorphism, Single Nucleotide; Risk Assessment; 3. Good health; 03 medical and health sciences; Cross-Sectional Studies; HIV-1; Humans; RNA, Viral; Female; Genetic Predisposition to Disease; Interferons

The critical role of interleukin-28B (IL28B)/interferon-λ3 (IFN-λ3) polymorphisms on the susceptibility to hepatitis C virus infection and the response to peginterferon-ribavirin therapy has encouraged exploration of similar effects on other viruses. Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection.