Oral human papillomavirus infection in HIV-negative and HIV-infected MSM

• DOI: 10.1097/qad.0b013e328362395c
• Publication Date: 2013-04-23T13:34:24Z
• Authors: Sofie H. Mooij; Hein J. Boot; Arjen G.C.L. Spek...; Ineke G. Stolte; Chris J.L.M. Meijer; Peter J.F. Snijders; Dominique W.M. Ve...; Audrey J. King; Henry J.C. de Vries; Wim G.V. Quint; Marianne A.B. van...; Maarten F. Schim ...
• Keywords: Adult; Male; Mouth; Papillomavirus Infections; HIV Infections; Middle Aged; Polymerase Chain Reaction; 3. Good health; Cohort Studies; Immunoenzyme Techniques; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Surveys and Questionnaires; DNA, Viral; Prevalence; Humans; Homosexuality, Male; Mouth Diseases; Papillomaviridae; Netherlands; Retrospective Studies

Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM.Analysis of baseline data from a prospective cohort study.MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay [short PCR fragment (SPF)10-PCR-DNA Enzyme Immuno Assay (DEIA)/LiPA25 system].In 2010-2011, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years [interquartile range (IQR) 34.8-47.5] and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8 and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM.Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.