Effects of in Utero Antiretroviral Exposure on Longitudinal Growth of HIV-Exposed Uninfected Infants in Botswana

• DOI: 10.1097/qai.0b013e3181ffa4f5
• Publication Date: 2010-12-02T10:16:27Z
• Authors: Kathleen M Powis; Laura Smeaton; Anthony Ogwu; Shahin Lockman; Scott Dryden-Pete...; Erik van Widenfelt; Jean Leidner; Joseph Makhema; Max Essex; Roger L Shapiro
• Keywords: Adult; Male; 2. Zero hunger; Botswana; Anthropometry; Infant, Newborn; Infant; HIV Infections; 3. Good health; 03 medical and health sciences; Child Development; 0302 clinical medicine; Pregnancy; Antiretroviral Therapy, Highly Active; Prenatal Exposure Delayed Effects; Body Size; Humans; Female; Pregnancy Complications, Infectious

Background: The impact of in utero exposure to highly active antiretroviral therapy (HAART) on longitudinal growth HIV-uninfected infants is unknown. Methods: Mashi and Mma Bana PMTCT intervention trials enrolled HIV-infected pregnant women at four sites Botswana. Breast-fed (BF), born 37 weeks or greater were included this analysis. Weight-for-age (WAZ), length-for-age (LAZ), weight-for-length (WLZ) z-scores calculated using World Health Organization Child Growth Standards. Mean compared between groups Student t test, response profiles analysis, general linear mixed effects modeling. Results: 619 HAART-exposed 440 zidovudine-exposed, was evaluated. birth weights 3.01 kg for HAART 3.15 zidovudine-exposed (P < 0.001) with lower mean WAZ, among (all P 0.001). had improvement WAZ from through 2 months = 0.03, 0.001, respectively). did not differ 3 6 0.26). Length-for-age (LAZ) remained but the incidence wasting stunting groups. Conclusions: Lower uninfected rapidly corrected during first life.