Diffusion-Weighted Magnetic Resonance Imaging of Breast Lesions

• DOI: 10.1097/rct.0b013e318165dc6b
• Publication Date: 2009-02-02T08:51:51Z
• Authors: Gladys G. Lo; Victor Ai; John K.F. Chan; K.W. Li; Polly S.Y. Cheung; T.T. Wong; Micheal Ma; Raymond Lee; Daisy Chien
• Keywords: Dynamic contrast; Breast MRI; Dynamic Contrast-Enhanced MRI; Gold standard (test)

Purpose: Dynamic contrast-enhanced magnetic resonance imaging (MRI) has been established as a valuable tool for the detection of breast cancer. There is evidence suggesting that diffusion-weighted (DWI) may be useful to distinguish between malignant and benign lesions. We seek evaluate ability DWI differentiate lesions at 3 T. Methods: MRI breasts were performed in 31 female patients (age: mean, 46 years; range, 34-69 years) with suspected on mammography ultrasound using 3-T scanner (MAGNETOM Tim Trio; Siemens Medical Solutions, Erlangen, Germany). Each lesion was assigned either or benign, blinded results ultrasound, according their characteristics MRI, DWI, apparent diffusion coefficient (ADC) measurements. Tissue samples obtained from all by needle excision biopsy. Using histological gold standard, diagnostic accuracies dynamic ADC calculated compared. Results: All (n = 31) identified both scans. The threshold value determined 0.00121 mm2/s, below which considered malignant. sensitivities/specificities qualitative quantitative 95%/91%, 95%/63.6%, 90%/91%, respectively. differences sensitivities, specificities, positive negative predictive values, examinations statistically insignificant. Conclusions: Diffusion-weighted T highly sensitive even assessment alone, whereas measurement offers increases specificity more than 90%. Further studies involving larger cohort size wider spectrum are indicated.