Contribution of Diffusion-Weighted Magnetic Resonance Imaging in the Characterization of Hepatocellular Carcinomas and Dysplastic Nodules in Cirrhotic Liver

• DOI: 10.1097/rct.0b013e3181da3671
• Publication Date: 2010-07-22T09:41:59Z
• Authors: Peng-Ju Xu; Fu-Hua Yan; Jian-Hua Wang; Yan Shan; Yuan Ji; Cai-Zhong Chen
• Keywords: HCCS; Nodule (geology)

Objectives: To evaluate the diagnostic value of diffusion-weighted magnetic resonance imaging (DWI) for characterization hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in cirrhotic liver, compared with contrast material-enhanced (CE-MRI). Methods: A total 54 patients 40 HCC 19 DN lesions were included our study, all histopathologically confirmed. All evaluated CE-MRI, breath-hold DWI was performed b = 500 s/mm2. The signal intensity (SI) classified as low, iso-, slightly high, strongly high SI that surrounding liver parenchyma on qualitative assessment. Apparent diffusion coefficients (ADCs) lesion-to-liver ADC ratio HCCs DNs measured by using Mann-Whitney U test. characterized use CE-MRI criteria DWI, respectively. Receiver operating characteristic analysis to assess these techniques combined differentiation from DNs. Results: In analysis, among HCCs, 39 (97.5%) had or 1 (2.5%) low SI; only 4 (21.5%) SI, 15 (78.95%) iso-SI SI. mean (SD) (1.28 × 10−3 [0.25] mm2/s 0.88 [0.15], respectively) significantly lower (P < 0.01 P 0.001, than those (1.53 [0.33] 1.00 [0.08], respectively). area, Az, under receiver curve feature, ratio, ADCs based diagnosis versus 0.88, 0.81, 0.68, When lesion a cutoff less 0.92 applied criterion, sensitivity, specificity, accuracy 67.50%, 94.74%, 76.27%, corresponding 0.70, 82.50%, 57.89%, 74.58%, Combined plus 0.91 97.50% 93.22% accuracy, which increased alone. Conclusions: Diffusion-weighted MRI can provide additional information differentiate DN. allows improved liver.