Contribution of Diffusion-Weighted Magnetic Resonance Imaging in the Characterization of Hepatocellular Carcinomas and Dysplastic Nodules in Cirrhotic Liver
HCCS
Nodule (geology)
DOI:
10.1097/rct.0b013e3181da3671
Publication Date:
2010-07-22T09:41:59Z
AUTHORS (6)
ABSTRACT
Objectives: To evaluate the diagnostic value of diffusion-weighted magnetic resonance imaging (DWI) for characterization hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in cirrhotic liver, compared with contrast material-enhanced (CE-MRI). Methods: A total 54 patients 40 HCC 19 DN lesions were included our study, all histopathologically confirmed. All evaluated CE-MRI, breath-hold DWI was performed b = 500 s/mm2. The signal intensity (SI) classified as low, iso-, slightly high, strongly high SI that surrounding liver parenchyma on qualitative assessment. Apparent diffusion coefficients (ADCs) lesion-to-liver ADC ratio HCCs DNs measured by using Mann-Whitney U test. characterized use CE-MRI criteria DWI, respectively. Receiver operating characteristic analysis to assess these techniques combined differentiation from DNs. Results: In analysis, among HCCs, 39 (97.5%) had or 1 (2.5%) low SI; only 4 (21.5%) SI, 15 (78.95%) iso-SI SI. mean (SD) (1.28 × 10−3 [0.25] mm2/s 0.88 [0.15], respectively) significantly lower (P < 0.01 P 0.001, than those (1.53 [0.33] 1.00 [0.08], respectively). area, Az, under receiver curve feature, ratio, ADCs based diagnosis versus 0.88, 0.81, 0.68, When lesion a cutoff less 0.92 applied criterion, sensitivity, specificity, accuracy 67.50%, 94.74%, 76.27%, corresponding 0.70, 82.50%, 57.89%, 74.58%, Combined plus 0.91 97.50% 93.22% accuracy, which increased alone. Conclusions: Diffusion-weighted MRI can provide additional information differentiate DN. allows improved liver.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (34)
CITATIONS (85)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....