Value of In Vivo T2 Measurement for Myocardial Fibrosis Assessment in Diabetic Mice at 11.75 T

• DOI: 10.1097/rli.0b013e318243e062
• Publication Date: 2012-04-06T20:38:14Z
• Authors: Sok-Sithikun Bun; Frank Kober; Alexis Jacquier; Leon Espinosa; Jérôme Kalifa; Marie-France Bonzi; Francis Kopp; Nathalie Lalevee; Stephane Zaffran; Jean-Claude Deharo; Patrick J. Cozzone; Monique Bernard
• Keywords: Myocardial fibrosis; Value (mathematics)

Objective: The aim of the study was to assess value in vivo T2 measurements noninvasively quantify myocardial fibrosis diabetic mice at 11.75 T. Diabetic cardiomyopathy is characterized by extracellular matrix alteration and microcirculation impairment. These conditions might provide electrical heterogeneity, which a substrate for arrhythmogenesis. T1 mapping has been proposed diffuse cardiac diseases but several limitations. measurement may represent an alternative quantification high magnetic field. Materials Methods: A resonance imaging protocol including T performed 9 male C57BL/6J after 8 weeks streptozotocin-induced diabetes control mice. Programmed ventricular stimulation both groups. were compared with histologic using picrosirius red staining. Results: Myocardial significantly lower (13.8 ± 2.8 ms) than controls (18.9 2.3 ms, P < 0.001). There good correlation between area obtained histopathology (R2 = 0.947, During programmed stimulation, 3 nonsustained tachycardias induced versus none group. Conclusions: relaxation time strongly correlated assessed staining