The Effect of High-Dose Radioiodine Treatment on Lacrimal Gland Function in Patients With Differentiated Thyroid Carcinoma

• DOI: 10.1097/rlu.0b013e318124fdb6
• Publication Date: 2007-08-09T07:01:34Z
• Authors: Armaghan Fard-Esf...; Hossein Mirshekar...; Babak Fallahi; Mohammad Eftekhari; Mohsen Saghari; Davood Beiki; Kianoush Ansari-G...; Abbas Takavar
• Keywords: Schirmer test; Dry mouth; Radioiodine therapy

Purpose: There are a limited number of case reports confirming the radioiodine (I-131) presence in tears and only few lacrimal gland dysfunction after I-131 therapy. This study was designed to clarify whether function can be affected by Materials Methods: We studied 100 eyes 50 patients who had received high doses for treatment differentiated thyroid carcinoma age- sex-matched control individuals without history interfering conditions. The exposed group at least 3 months their last Dry eye symptoms Schirmer test values (wetting level millimeters per 5 minutes) an were compared with those unexposed group. Results: Fifty-one percent 50% ones revealed 1 dry symptoms. no significant difference between 2 groups, except burning sensation redness, which significantly higher eyes. A lower value noted group, 14.5 ± 10.8 mm, when that controls, 18.2 11.0 mm (P = 0.016), relative risk abnormal cases 1.78 0.62. Correlation coefficient analysis showed relationship cumulative administered I-131. Conclusions: Reduction tear secretion from glands is seen high-dose therapy; however, greater than population.