Increased Right Ventricular Glucose Metabolism in Patients With Pulmonary Arterial Hypertension

• DOI: 10.1097/rlu.0b013e3182177389
• Publication Date: 2011-08-06T09:37:42Z
• Authors: Mehmet Mustafa Can; Cihangir Kaymaz; Ibrahim Halil Tan...; Hacer Ceren Tokgoz; Nesrin Canpolat; Erdem Turkyilmaz; Kenan Sonmez; Nihal Ozdemir
• Keywords: Brain natriuretic peptide

We aimed to assess the characteristics of glucose utilization in left and right ventricle (LV, RV) myocardium with F-18 fluorodeoxyglucose (FDG) on positron emission tomography patients pulmonary arterial hypertension (PAH), evaluate whether predominance RV metabolism as compared that LV relates clinical, hemodynamic, echocardiographic, neurohormonal parameters.The study group comprised 23 PAH 16 healthy controls who underwent FDG tomography. The ratio uptake (u) those was used a marker for by myocardium. Six-minute walking distance, plasma brain natriuretic peptide (BNP), planimetric echo measures areas, systolic pressure estimated Doppler, Tei index, tricuspid annular excursion, tissue velocity (St) were function.The had significantly higher SUV ratios controls. FDGu showed high correlation PAPs (r=0.87, P<0.05), BNP (r=0.63, area (r=0.61, P<0.05); mild index (r=0.47, inverse excursion (r=-0.80, 6-minute distance (r=-0.74, St (r=-0.68, P<0.05).Increased accumulation indicates increased loading correlates prognostic markers including reduced exercise capacity, elevated BNP, variables function. Moreover, identification predicts presence but not severity pressure.