Accuracy of Central Benzodiazepine Receptor Binding Potential/Cerebral Blood Flow SPECT Imaging for Detecting Misery Perfusion in Patients With Unilateral Major Cerebral Artery Occlusive Diseases

• DOI: 10.1097/rlu.0b013e31823ea69f
• Publication Date: 2012-02-03T17:12:43Z
• Authors: Hiroki Kuroda; Kuniaki Ogasawara; Taro Suzuki; Kohei Chida; Kenta Aso; Masakazu Kobayashi; Kenji Yoshida; Kazunori Terasaki; Shunrou Fujiwara; Yoshitaka Kubo; Akira Ogawa
• Keywords: Emission computed tomography; Acetazolamide; Spect imaging

The aim of the present study was to determine whether central benzodiazepine receptor binding potential (BRBP)/cerebral blood flow (CBF) or a combination CBF and cerebrovascular reactivity (CVR) acetazolamide on single-photon emission computed tomography (SPECT) more accurately detects misery perfusion, indicating elevation absolute value oxygen extraction fraction (OEF) positron (PET), in patients with unilateral major cerebral artery occlusive diseases.In 84 patients, OEF, CBF, CVR acetazolamide, BRBP were assessed using ¹⁵O-PET N-isopropyl-p-[¹²³I]-iodoamphetamine [¹²³I]-iomazenil SPECT, respectively. A region interest automatically placed middle territory 3-dimensional stereotactic template.Sensitivity, specificity, positive negative predictive values for affected side-to-contralateral side asymmetry SPECT-BRBP/CBF detect abnormally elevated PET-OEF hemisphere 100%, 86.4%, 66.7%, Area under receiver operating characteristic curve detecting did not differ between analysis SPECT-CBF SPECT-CVR (0.89; 95% confidence interval, 0.80-0.94) that (0.93; 0.86-0.97). 3 detected 97.0% specificity 90.0% value.The accuracy BRBP/CBF SPECT is equivalent perfusion disease.