The Effect of Continuous Release of Recombinant Human Epidermal Growth Factor (rh-EGF) in Chitosan Film on Full Thickness Excisional Porcine Wounds

• DOI: 10.1097/sap.0b013e31815bfeac
• Publication Date: 2008-09-22T07:15:15Z
• Authors: Joon Pio Hong; Yeun Wha Kim; Sang Kil Lee; Sun Hee Kim; Kyung Hyun Min
• Keywords: Chitosan; Drug Carriers; Wound Healing; Epidermal Growth Factor; Swine; Wounds, Penetrating; Recombinant Proteins; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Delayed-Action Preparations; Animals; Humans; Bandages, Hydrocolloid; Skin

The purpose of this article is to evaluate the effect continuously released recombinant human epidermal growth factor (rh-EGF) in chitosan film full thickness porcine wounds. A total 10 domestic pigs (Yorkshire species) weighing 18 22 kg between ages 50 60 days were used. wounds divided into 3 groups and treated selectively with rh-EGF (EGF 20 ug/wound/d), without rh-EGF, or remained as control group. One hundred percent healing time was observed, hematoxylin eosin Anti Ki-67 antibody immunohistochemical staining performed. 100% showed statistical significance film-treated group against (P < 0.05). But it did not reveal any over In preliminary study, although continuous release accelerates epithelialization, benefit combination cannot be determined use alone. Further analysis using complex wound models such diabetes infection, which may have different pathology healing, will needed potential benefit/synergistic effectiveness.