TREATMENT WITH H2S-RELEASING DICLOFENAC PROTECTS MICE AGAINST ACUTE PANCREATITIS-ASSOCIATED LUNG INJURY

• DOI: 10.1097/shk.0b013e31806ec26
• Publication Date: 2007-07-06T08:21:34Z
• Authors: Madhav Bhatia; Jenab N. Sidhapur...; Anna Sparatore; Philip K. Moore
• Keywords: Diclofenac

Impaired lung function in severe acute pancreatitis is the primary cause of morbidity and mortality this condition. Hydrogen sulfide (H(2)S) a naturally occurring gas that has been shown to be potent vasodilator. Diclofenac nonsteroidal anti-inflammatory drug have anti-inflammatory, analgesic, antipyretic activity. ACS15 an H(2)S-releasing derivative diclofenac. Little known about its effectiveness as drug. In report, we describe effect diclofenac on associated injury mouse. Acute was induced mice by hourly i.p. injections cerulein. were administered either 1 hour before or after starting cerulein injections, severity assessed. The determined hyperamylasemia, neutrophil sequestration pancreas (pancreatic myeloperoxidase activity), pancreatic acinar cell injury/necrosis histological examination sections. pancreatitis-associated assessed lungs (lung activity) ACS15, given prophylactically therapeutically, significantly reduced inflammation without having any significant injury. These results suggest usefulness drugs potential treatments for