HUMAN CHOLESTERYL ESTER TRANSFER PROTEIN EXPRESSION ENHANCES THE MOUSE SURVIVAL RATE IN AN EXPERIMENTAL SYSTEMIC INFLAMMATION MODEL

• DOI: 10.1097/shk.0b013e31816e30fd
• Publication Date: 2008-10-11T15:31:49Z
• Authors: Patrícia M. Cazita; Denise F. Barbeiro; Ana I.S. Moretti; Eder C.R. Quintão; Francisco G. Soriano
• Keywords: Cholesterylester transfer protein; Proinflammatory cytokine; Cholesteryl ester; Wild type; Adoptive Cell Transfer; Intraperitoneal injection

Mice expressing human cholesteryl ester transfer protein (huCETP) are more resistant to Escherichia coli bacterial wall LPS because death rates 5 days after intraperitoneal inoculation of were higher in wild-type than huCETP+/− mice, whereas all huCETP+/+ mice remained alive. After inoculation, plasma concentrations TNF-α and IL-6 increased less mice. vitro elicited lower production by CETP macrophages. In addition, RAW 264.7 murine macrophages on incubation with but decreased a dose-dependent manner when was added the medium. Human enhanced binding high-density lipoprotein/low-density lipoprotein. The liver uptake intravenous infused 14C-LPS from Salmonella typhimurium greater Present data indicate for first time that is an endogenous component involved line defense against exacerbated proinflammatory mediators.