Macrophage-Produced IL-12p70 Mediates Hemorrhage-Induced Damage in a Complement-Dependent Manner

• DOI: 10.1097/shk.0b013e3181ed8ec9
• Publication Date: 2010-06-24T09:47:07Z
• Authors: Diana J. Hylton; Sara M. Hoffman; N. Van Rooijen; Stephen Tomlinson; Sherry D. Fleming
• Keywords: Complement

Hemorrhage and hemorrhagic shock instigate intestinal damage inflammation. Multiple components of the innate immune response, including complement neutrophil infiltration, are implicated in this pathology. To investigate interaction activation other response during hemorrhage, we treated mice after hemorrhage with CR2-fH, a targeted inhibitor alternative pathway assessed inflammation 2 h hemorrhage. In wild-type mice, CR2-fH attenuated hemorrhage-induced, midjejunal as determined by decreased mucosal damage, macrophage leukotriene B4, IL-12p40, TNF-[alpha] production. The critical nature infiltration to was further using pretreated clodronate-containing liposomes. absence either macrophages or IL-12p70 damage. These data suggest that production hemorrhage-induced