Systemic Lidocaine Shortens Length of Hospital Stay After Colorectal Surgery

• DOI: 10.1097/sla.0b013e31805dac11
• Publication Date: 2007-07-23T08:04:05Z
• Authors: Susanne Herroeder; Sabine Pecher; Marianne E. Schön...; Grit Kaulitz; Klaus Hahnenkamp; Helmut Friess; Bernd W. Böttiger; Harry Bauer; oMarcel G. W. Dij...; Marcel E. Durieux; Markus W. Hollmann
• Keywords: Bolus (digestion)

To characterize the beneficial effects of perioperative systemic lidocaine on length hospital stay, gastrointestinal motility, and inflammatory response after colorectal surgery.Surgery-induced stimulation plays a major role in development several postoperative disorders. Local anesthetics possess anti-inflammatory activity are thought to positively affect patients' outcome surgery. This double-blinded, randomized, placebo-controlled trial aimed evaluate provide insights into underlying mechanisms.Sixty patients undergoing surgery, not willing or unable receive an epidural catheter, were randomly assigned placebo treatment. Before induction general anesthesia, intravenous bolus (1.5 mg/kg) was administered followed by continuous infusion (2 mg/min) until 4 hours postoperatively. Length pain scores recorded plasma levels expression pro- mediators determined.Lidocaine significantly accelerated return bowel function shortened stay one day. No difference could be observed daily ratings. Elevated IL-6, IL-8, complement C3a, IL-1ra as well CD11b, L- P-selectin, platelet-leukocyte aggregates attenuated lidocaine.Perioperative only improved motility but also significantly. Anti-inflammatory modulating surgery-induced stress may potential mechanism. Systemic thus convenient inexpensive approach improve for suitable anesthesia.