Predicting Systemic Disease in Patients With Esophageal Cancer After Esophagectomy

• DOI: 10.1097/sla.0b013e3181904f3c
• Publication Date: 2008-12-17T08:14:34Z
• Authors: Christian G. Peyre; Jeffrey A. Hagen; Steven R. DeMeester; Jan J. B. Van Lan...; Arnulf Hölscher; Simon Law; Alberto Ruol; Ermanno Ancona; S Michael Griffin; Nasser K. Altorki; Thomas W. Rice; John Wong; Toni Lerut; Tom R. DeMeester
• Keywords: Esophagectomy

In Brief Objective: The aim of this study was to determine whether the risk systemic disease after esophagectomy can be predicted by number involved lymph nodes. Summary Background Data: Primary is curative in some but not all patients with esophageal cancer. Identification at high for would allow selective use additional therapy. This a multinational, retrospective review treated resection alone assess impact nodes on probability disease. Methods: population included 1053 cancer (700 adenocarcinoma, 353 squamous carcinoma) who underwent R0 ≥15 resected 9 international centers: Asia (1), Europe (5), and United States (3). To ensure minimum potential follow-up 5 years, only had before October 2002 were included. Patients neoadjuvant or adjuvant therapy excluded. recurrence assessed using univariate multivariate analyses. Results: Systemic occurred 40%. ranged from 0 26 55% having least 1 node. frequency 16% those without nodal involvement progressively increased 93% 8 more Conclusions: shows that used predict likelihood exceeds 50% when 3 are approaches 100% more. Additional warranted these an independent predictor esophagectomy. Furthermore, stratify guide