Pretreatment T3-4 Stage is an Adverse Prognostic Factor in Patients with Esophageal Squamous Cell Carcinoma Who Achieve Pathological Complete Response Following Preoperative Chemoradiotherapy

• DOI: 10.1097/sla.0b013e3181949e9f
• Publication Date: 2009-05-21T10:21:00Z
• Authors: Yin-Kai Chao; Sheng-Chieh Chan; Yun-Hen Liu; Huan-Wu Chen; Yung-Liang Wan; Hsien-Kun Chang; Kang-Hsing Fan; Hui-Ping Liu
• Keywords: Esophagectomy; Chemoradiotherapy; Univariate analysis

Preoperative chemoradiotherapy (CRT) followed by esophagectomy is becoming one of the standard treatment strategies for esophageal cancer. Pathologic complete response (pCR) after CRT best predictor survival in squamous cell carcinoma (SCC) esophagus. Although no adjuvant recommended individuals who achieve pCR, approximately 30% these patients develop recurrence. Herein we sought to retrospectively investigate independent predictors tumor recurrence this patient group.Between 1995 and 2004, investigated seventy (69 males 1 female; mean age: 56.1 years) with SCC achieved pCR following preoperative chemoradiotherapy. Study end points included recurrence, disease-specific (DSS), disease-free (DFS). Univariate multivariate analyses were used identify risk factors study points.Mean follow-up time survived was 65.8 months. At analysis, 18 (25.7%) died disease 22 (31.4%) developed Multivariate analysis showed that pretherapy T3-4 most important adverse factor (P = 0.007), DFS 0.005), DSS 0.026). The 5-year 45% clinical 85% those T1-2 0.02).We have shown up 31.4% thereafter. Pretherapy a strong DFS. High-risk should be strict surveillance protocol.