Early Diagnosis of Intestinal Ischemia Using Urinary and Plasma Fatty Acid Binding Proteins

• DOI: 10.1097/sla.0b013e318207a767
• Publication Date: 2010-12-21T04:53:30Z
• Authors: Geertje Thuijls; Kim van Wijck; Joep Grootjans; Joep P. M. Derikx; Annemarie A. van ...; Erik Heineman; Cornelis H.C. Dejong; Wim A. Buurman; Martijn Poeze
• Keywords: Intestinal Ischemia

This study aims at improving diagnosis of intestinal ischemia, by measuring plasma and urinary fatty acid binding protein (FABP) levels.Fifty consecutive patients suspected ischemia were included blood urine sampled time suspicion. Plasma concentrations FABP (I-FABP), liver (L-FABP) ileal bile (I-BABP) measured using enzyme-linked immunosorbent assays.Twenty-two diagnosed with 24 other diseases, 4 excluded from further analysis fulfilling exclusion criteria. Median I-FABP L-FABP all 3 markers significantly higher in proven than final diagnoses (plasma I-FABP; 653 pg/mL vs. 109 pg/mL, P = 0.02, L-FABP; 117 ng/mL 25 ng/mL, 0.006, 3377 115 0.001, 1,199 37 =0.004, I-BABP; 48.6 0.6 0.002). Positive negative likelihood ratios increased positive posttest probability decreased on ischemia. In a trend to I-BABP levels was observed when the ileum involved (18.4 2.9 0.05).Plasma especially can improve early Furthermore, help localizing