Outcomes in Pediatric Melanoma

• DOI: 10.1097/sla.0b013e318217e852
• Publication Date: 2011-03-30T07:49:01Z
• Authors: Stacey Moore-Olufemi; Cynthia Herzog; Carla Warneke; Jerry E. Gershenwald; Paul Mansfield; Merrick Ross; Victor Prieto; Kevin P. Lally; Andrea Hayes-Jordan
• Keywords: Male; Skin Neoplasms; Adolescent; Databases, Factual; Sentinel Lymph Node Biopsy; Age Factors; Infant; Prognosis; Survival Analysis; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Child, Preschool; Lymphatic Metastasis; Humans; Female; Lymph Nodes; Child; Melanoma; Retrospective Studies

The aim of this study was to determine the influence age on outcome in pediatric melanoma patients and identify factors associated with positive lymph node status population.A retrospective review a prospective database, using sentinel biopsy (SLNB), from 1992 2006, identified 109 primary diagnosis melanoma. Patient dichotomized as prepubescent (<10 years age) adolescent (≥10-18 age). Factors investigated included patient race, sex, tumor thickness, Spitzoid or Non-Spitzoid histology, radial growth phase, vascular invasion. Fisher's exact test used compare groups. Time-to-event analysis performed Kaplan-Meier method.There were 25 84 patients. Prepubescent more often non-White, had greater spitzoid tumors Ten-year overall survival (OS) 89% 10-year event-free (EFS) 73%. Among 57 who an SLNB, prepubertal higher percentage positivity. odds having SLNB decreased by 13% each year increasing age. Patients thickness ≥2.01 mm compared those ≤1.0.This is largest known Although OS EFS did not differ groups, younger ages showed increased risk metastasis thicker tumors. This suggests that may have disease differs biologically older