Nitazoxanide and Probiotics for the Treatment of Recurrent Clostridium difficile Infection in a Peritoneal Dialysis Patient

• DOI: 10.1097/smj.0b013e3181a82bbb
• Publication Date: 2011-04-06T22:35:41Z
• Authors: Bienvenido G. Yangco; Gulab Sher; Matthew C. Bardin
• Keywords: 0301 basic medicine; 0303 health sciences; Antiparasitic Agents; Clostridioides difficile; Gastrointestinal Diseases; Probiotics; Middle Aged; Nitro Compounds; 3. Good health; Thiazoles; 03 medical and health sciences; Clostridium Infections; Humans; Kidney Failure, Chronic; Female; Peritoneal Dialysis

Nitazoxanide has been proven to be efficacious for the treatment of Clostridium difficile infection (CDI), but data is limited in peritoneal dialysis (PD) patients. This report details the successful utilization of nitazoxanide and probiotics to treat multirecurrent CDI in a PD patient. A 58-year-old woman was admitted with hypotension, nausea and vomiting attributed to metronidazole therapy for CDI, her third CDI treatment regimen in 3 months. During her admission, the patient developed CDI and was started on a 6-week regimen of nitazoxanide and probiotics to assist in re-establishing the colonic flora. The regimen was well tolerated and the patient remained disease free at follow up, four months later.